| Paper | |
|---|---|
| (POINT) Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA _____ A RCT assigning patients with low NIHSS (<4) stroke or high-risk TIA (ABCD2>3) to aspirin + clopidogrel vs aspirin alone within 12 hours of event, finding significantly fewer major ischemic events in the DAPT group at 90 days (most in the first week), but significantly more major hemorrhagic events. | LINK |
| (CHANCE) Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack _____ A RCT assigning patients with low NIHSS (<4) stroke or high-risk TIA (ABCD2>3) to aspirin + clopidogrel for 21 days followed by clopidogrel alone vs aspirin + placebo within 24 hours of event, finding significantly fewer strokes in the DAPT group at 90 days with no difference in hemorrhage. | LINK |
| (THALES) Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA _____ A RCT assigning patients with low-moderate (NIHSS<6) or high-risk TIA (ABCD2>5) to ticagrelor + aspirin for 30 days vs placebo + aspirin, finding significantly reduced risk of stroke or death in the DAPT group, significantly increased severe hemorrhage in the DAPT group, and no difference in disability between groups. | LINK |