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Fluoxetine for Motor Recovery Post-Stroke

Paper
(FLAME) Fluoxetine for motor recovery after acute ischaemic stroke: a randomised placebo-controlled trial
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A small French RCT comparing fluoxetine to placebo for motor recovery post-stroke, suggesting significant improvement in motor recovery at 3 months in the fluoxetine group
LINK
(FOCUS) Effects of fluoxetine on functional outcomes after acute stroke: a pragmatic, double-blink, randomised, controlled trial
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A larger UK RCT comparing fluoxetine to placebo for functional recovery post-stroke, finding no significant difference in 6 month functional status between groups, though fluoxetine use was associated with lower rates of new depression and higher rates of bone fractures
LINK