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Anticoagulation in the Frail Elderly

Paper
(ELDERCARE-AF) Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
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A Japanese RCT suggesting that half-dose edoxaban is superior to placebo for stroke reduction without significantly increased major bleeding or death in elderly patients
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Effectiveness and Safety of Anticoagulation Therapy in Frail Patients With Atrial Fibrillation
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A Korean retrospective cohort suggesting that frail elderly have reduced risk of ischemic stroke and death on oral anticoagulation vs no oral anticoagulation without increase in major bleeding
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